Peer-Reviewed Publications

1. Watts, S., Wheeler, C., Morse, R., and Goodenow, R.S. “Amino acid comparison of the

class I antigens of mouse major histocompatibility complex”, Immunogenetics 30, 390-392


2. Watts, S., Cranmer Davis, A., Gaut, B., Wheeler, C., Hill, L., and Goodenow, R.S.

“Organization and structure of the Qa genes of the major histocompatibility complex of the

C3H mouse: implications for Qa function and class I evolution”, EMBO J. 8, 1749-1759


3. Wheeler, C.J., Maloney, D., Fogel, S., and Goodenow, R.S. “Microconversion between

murine MHC class I genes integrated into yeast”, Nature 347, 192-194 (1990)

4. Wheeler, C.J., von Hoegen, P., and Parnes, J.R. “An immunological role for the CD8β-

chain”, Nature 357, 247-249 (1992) 

5. Wheeler, C.J., Chen, J.-Y., Potter, T., and Parnes, J.R. “Mechanisms of CD8β-mediated T

cell response enhancement: Interaction with MHC class I/β2-microglobulin and functional

coupling to TCR/CD3”, J. Immunol. 160, 4199-4207 (1998)

6. Yu, J., Wheeler, C.J., Lee, P.K., Prins, R., Lau, R., Zhang, W., Zeltzer, P., and Black, K.L. “

Vaccination of malignant glioma patients with peptide-pulsed dendritic cells elicits systemic

cytotoxicity and intracranial T-cell infiltration”, Cancer Res 61, 842-847 (2001)

7. Liu, Y., Ehtesham, M., Samoto, K., Wheeler, C.J., Thompson, R.C., Villareal, L.P., Black,

K.L., and Yu, J.S. “In situ adenoviral Interleukin-12 gene transfer confers potent and longlasting

cytotoxic immunity in glioma. Cancer Gene Therapy 9: 9-15 (2002)

8. Yu, J.S., Lee, P.K., Ehtesham, M., Samoto, K., Black, K.L., and Wheeler , C.J.

“Intratumoral T cell subset ratios and fas ligand expression on brain tumor endotheliu”, J

Neuro-oncol 64, 55-61 (2003)

9. Prins, R.M., Graf, M.R., Merchant, R.E., Black, K.L., and Wheeler , C.J. “Deficits in thymic

function and output of recent thymic emigrant T cells during intracranial glioma

progression”, J Neuro-oncol 64, 45-54 (2003)

10. Liu, G., Khong, H.T., Wheeler, C.J., Yu, J.S., Black, K.L., and Ying, H. “ Molecular and

functional analysis of tyrosinase-related protein (TRP)-2 as a cytotoxic T lymphocyte target

in patients with malignant glioma”, J Immunother 26, 301-312 (2003)

11. Wheeler, C.J., Black, K.L., Liu, G., Gutierrez, M., Ying, H., Yu, J.S., Zhang, W., and Lee,

P.K. “Thymic CD8+ T cell production strongly influences tumor antigen recognition and agedependent

glioma mortality”, J Immunol 171, 4927-4933 (2003)

12. Prins, R.M.*, Incardona, F.*, Lau, R., Lee, P.K., Black, K.L., Claus, S., Zhang, W., and

Wheeler, C.J. “Characterization of defective CD4-8- T cells in murine tumors generated

independent of antigen specificity” J Immunol 172, 1602-1611 (2004)

*equal contributors

13. Liu, G., Ying, H., Zeng, G., Dudley, M.E., Wheeler, C.J., Black, K.L., and Yu, J.S. “HER-2,

gp100 and MAGE-1 are expressed in human glioblastoma and recognized by cytotoxic T

cells”, Cancer Res 64:4980-4986 (2004)

14. Yu, J.S., Liu, G., Ying, H., Yong, W.H., Black, K.L., and Wheeler, C.J. “Vaccination with

tumor lysate-pulsed dendritic cells elicits specific cytotoxic T cells in patients with malignant

glioma”, Cancer Res 64:4973-4979 (2004)

15. Wheeler, C.J., Das, A., Liu, G., Yu, J.S., and Black, K. “ Clinical responsiveness of

glioblastoma multiforme to chemotherapy after vaccination”, Clin Cancer Res 10:5316-5326


16. Wheeler, C.J., Yu, J., and Black, K.L. (2004) Cellular immunity in the treatment of brain

tumors. Clinical Neurosurgery 51:132-139. 

17. Liu, G., Akasaki, Y., Khong, H.T., Wheeler, C.J., Das, A., Black, K.L., and Yu, J.S.

“Cytotoxic T cell targeting of TRP-2 sensitizes human malignant glioma to chemotherapy”,

Oncogene 24:5226-5234 (2005)

18. Wheeler, C.J., and Black, K.L. (2005) Vaccines and beneficial immunity in glioma patients.

Front Biosc 10:2861-2881 

19. Wheeler, C.J., and Black, K. (2005) Dendritic Cell Vaccines and Obstacles to Beneficial

Immunity in Glioma Patients. Current Opinion Mol Ther 7:35-47. 

20. Wheeler, C. J., K. L. Black, G. Liu, M. Wagenberg, X.-x. Zhang, S. Pepkowitz, D.

Goldfinger, H. Ng, D. Irvin, and J. S. Yu. “Vaccination elicits correlated immune and clinical

responses in patients with glioblastoma multiforme”, Cancer Res 68:5955-5964 (2008)

21. Wheeler, C. J., and K. L. Black. (2009) DCVax-Brain and DC vaccines in the treatment of

GBM. Expert Opin Investig Drugs 18:509.

22. Irvin, D., Duvall, G., Zhang, X-x., Zhai, Y., Sarayba, D., Seksenyan, A., Panwar, A., Black,

K.L., and Wheeler, C. J. “T cells enhance stem-like properties and conditional malignancy

in gliomas”, PlosONE 5 e10974 (2010)

23. Junes-Gill KS, Gallaher TK, Gluzman-Poltorak Z, Miller JD, Wheeler CJ, Fan X, Basile

LA. hHSS1: a novel secreted factor and suppressor of glioma growth located at chromosome

19q13.33. J Neurooncol. 102:197-211 (2011).

24. Wheeler CJ, Black KL. (2011) Vaccines for glioblastoma and high-grade glioma Expert Rev

Vaccines 10:875-86. 

25. Phuphanich S*, Wheeler CJ*, Rudnick JD, Mazer M, Wang H, Nuño MA, Richardson JE,

Fan X, Ji J, Chu RM, Bender JG, Hawkins ES, Patil CG, Black KL, Yu JS. "Phase I trial of a

multi-epitope-pulsed dendritic cell vaccine for patients with newly diagnosed glioblastoma”,

Cancer Immunol Immunother 62:125-35 (2013) PMID: 2284702 *equal contributors

26. Niesen CE, Xu J, Fan X, Li X, Wheeler CJ, Mamelak AN, Wang C. “Transcriptomic

profiling of human peritumoral neocortex tissues revealed genes possibly involved in tumorinduced

epilepsy”, PLoS ONE 8(2):e56077 (2013) PMID: 23418513

27. Cordner, R., Black, K.L., and Wheeler, C.J. (2013) The exploitation of adaptive evolution to

treat glioblastoma multiforme CNS Oncology 2:171-179.

28. Wheeler CJ, Seksenyan A, Koronyo Y, Rentsendorj A, Sarayba D, Wu H, Gragg A, Siegel

E, Thomas D, Espinosa A, Thompson K, Black K, Koronyo-Hamaoui M, Pechnick R, and

Irvin DK “T-lymphocyte deficiency exacerbates behavioural deficits in the 6-OHDA

unilateral lesion rat model for Parkinson’s Disease”, J Neurol Neurophysiol 5(3). pii: 209.


29. Jouanneau E, Black KL, Veiga L, Cordner R, Goverdhana, S, Zhai Y, Zhang X, Panwar A,

Mardiros A, Wang HQ, Gragg A, Zandian M, Irvin D, and Wheeler CJ “Intrinsically desialyated

CD103+ CD8 T cells mediate beneficial anti-glioma immune responses”, Cancer

Immunol Immunother 63:911-24 (2014)

30. Junes-Gill KS, Lawrence CE, Wheeler CJ, Cordner R, Gill TG, Mar V, Shiri L, Basile LA.

“Human Hematopoietic Signal peptide-containing Secreted 1 (hHSS1) modulates genes and

pathways in glioma: implications for the regulation of tumorigenicity and angiogenesis”,

BMC Cancer 14:920 (2014).

Book Chapters

Wheeler, C.J., Maloney, D., Arbeitman, M., Baldwin, D., Chan, H., Rufer, J., Fogel, S., and

Goodenow, R.S. (1990) Microgene conversion in the evolution of murine MHC class I genes.

in Transgenic mice and mutants in MHC research. Springer-Verlag, New York.

Wheeler, C.J., and Black, K.L. (2006) Vaccines and beneficial immunity in glioma patients. in

Gene therapy for neurological disorders. Castro, M.G. & Lowenstein, P.R., editors Taylor &

Francis, New York


Wheeler, C.J. Dendritic cell vaccines to combat glioblastoma (2010) .Expert Rev Neurother

10:483-6. PMID: 203671991.


Peer-Reviewed Publications

1.  Kinoshita Y, Jarell AD, Flaman JM, Foltz G, Schuster J, Sopher BL, Irvin DK, Kanning K, Kornblum HI, Nelson PS, Hieter P, Morrison RS. Pescadillo, a novel  cell cycle regulatory protein abnormally expressed in malignant cells. 2001 Journal of Biological Chemistry 276(9): 6656-65.

2.  Irvin DK, Zurcher SD, Nguyen T, Weinmaster G, Kornblum HI. Expression patterns of Notch1, Notch2, and Notch3 suggest multiple functional roles for the Notch-DSL signaling system during brain development. 2001 Journal of Comparative Neurology 436(2): 167-81. 

3.  Dhaka A, Costa RM, Hu H, Irvin DK, Patel A, Kornblum HI, Silva AJ, O'Dell TJ, Colicelli J. The RAS effector RIN1 modulates the formation of aversive memories. 2002 Journal of Neuroscience 23(3):748-57.

4.  Irvin DK, Dhaka A, Hicks C, Weinmaster G, Kornblum HI. Extrinsic and intrinsic factors governing cell fate in cortical progenitor cultures. 2003 Developmental Neuroscience 25(2-4):162-72.

5.  Easterday MC, Dougherty JD, Jackson RL, Ou J, Nakano I, Paucar AA, Roobini B, Dianati M, Irvin DK, Weissman IL, Terskikh AV, Geschwind DH, Kornblum HI. Neural progenitor genes. Germinal zone expression and analysis of genetic overlap in stem cell populations. 2003 Developmental Biology 264(2): 309-22. 

6.  Irvin DK, Nakano I, Paucar AA, Kornblum HI. Patterns of Jagged1, Jagged2, Delta-like 1 and Delta-like 3 expression during late embryonic and postnatal brain development suggests multiple functional roles in progenitors and differentiated cells. 2004 Journal of Neuroscience Research 75(3): 330-4

7.  Irvin DK, Yuan X, Tunici P, Yu JS.  Neural Stem Cells – A Promising Potential Therapy for Brain Tumors. 2006 Current Stem Cell Research & Therapy.

8.  Tunici P, Irvin DK, Liu G, Yuan X, Zhaohui Z, Ng H, Yu J, Brain Tumor Stem Cells: New Targets for Clinical Treatments. Neurosurgical Focus 20(4) E27, 2006.

9.  Andersson E, Irvin DK, Ahlsiö J  Parmar M. Ngn2 and Nurr1 act in synergy to induce midbrain dopaminergic neurons from expanded neural stem and progenitor cells. Experimental Cell Research. Apr 1; 313(6):1172-80

10.  Liu G, Yuan X, Zeng Z, Tunici P, Ng H, Abdulkadir IR, Lu L, Irvin DK, Black KL, Yu JS. Analysis of gene expression and chemoresistance of CD133+ cancer stem cells in glioblastoma. 2006 Molecular Cancer. Dec 2; 5:67.

11.  Hu J, Yuan X, Ko MK, Yin D, Sacapano MR, Wang X, Konda BM, Espinoza A, Prosolovich K, Ong JM, Irvin DK, Black KL. Calcium-activated potassium channels mediated blood-brain tumor barrier opening in a rat metastatic brain tumor model. 2007 Molecular Cancer. Mar 14;6:22.

12.  *Ghods-Jourabchi A, *Irvin DK, Gentao Liu G, Abdulkadir I, Yuan X, Tunici P, Wachsmann-Hogi S, Konda B, Black  K,  Yu J, Spheres Isolated from 9L Gliosarcoma Rat Cell Line Possess Chemoresistant and Aggressive Cancer Stem-Like Cells. 2007 Stem Cells Jul;25(7):1645-53 

13.  Yin D, Wang X, Konda B, Ong J, Hu J, Sacapano M, Ko M, Espinoza A, Irvin DK, Shu Y, Black K.  Increase in Brain Tumor Permeability in Glioma-bearing Rats with Nitric Oxide Donors. 2008 Clinical Cancer Research, Jun 15;14(12):4002-9.

14.  Irvin DK, Thompson L, Kirik D, Björklund A In Vivo Gene Delivery to Endogenous Striatal Progenitors Generated by a 6-hydroxydopamine Lesion of the Nigrostriatal Dopamine Pathway. 2008 Neurobiology of Disease. Jun; 30(3):343-52 (Selected as Cover Article).

15.  Black K, Yin D, Ong J, Hu J, Konda B, Wang X, Ko M, Bayan J, Sacapano M, Espinoza A, Irvin DK, Shu Y. Phosphodiesterase 5 Inhibitors Enhance Tumor Permeability and Efficacy of Chemotherapy in a Rat Brain Tumor Model, 2008 Brain Research, Sept. 1230:290-302.

16.  Black K, Yin D, Konda B, Wang X, Hu J, Ko M, Bayan J, Sacapano M, Espinoza A, Ong J, Irvin D, Shu Y, Different Effects of KCa and KATP Agonists on Brain Tumor Permeability between Syngeneic and Allogeneic Rat Models. 2008, Brain Research Aug 28;1227:198-206 (Selected as Cover Article).

17.  Wheeler C, Black K, Liu G, Wagenberg M, Zhang X, Pepkowitz S, Goldfinger D, Ng H, Irvin DK, Yu J. Vaccination with tumor lysate-pulsed dendritic cells elicits correlated immune and clinical response magnitudes in patients with glioblastoma multiforme. 2008 Cancer Research, Jul 15;68 (14):5955-64.

18.  Irvin DK, Jouanneau E, Duvall G, Zhang X, Zhai y, Sarayba D, Seksenyan A, Panwar A, Black KL, Wheeler CJ. T cell activity promotes stem-like properties, but not malignancy, in gliomas. 2010, PlosOne, Jun 7;5(6):e10974.

19.  Patil C, Yi A, Elramsisy A, Hu J, Mukherjee D, Irvin D, Yu J, Bannykh S, Black K, Nuño M. Prognosis of Patients with Multifocal Glioblastoma: A Case-Controlled Study. March 2012.  Journal of Neurosurgery

20.  Wheeler C, Wu H, Sarayba D, Gragg A, Siegel E, Thomas D, Andres E, Thompson K, Black KL, Pechnick P, IrvinD, T-lymphocytes influence behavioral deficits in the 6-OHDA unilateral lesion model for Parkinson’s disease. July 2014, Journal of Neurology & Neurophysiology. 

21.  Jouanneau, E., Black, K.L., Veiga, L., Goverdhana, S., Gragg, A., Zandian, M., Zhai, Y., Zhang, X-x., Mardiros, A., Wang, H.-Q., Panwar, A., Irvin, D., and Wheeler, C. J. Intrinsically de-sialylated CD103(+) CD8 T cells mediate beneficial anti-glioma immune responses. June 2014, Cancer Immunology, Immunotherapy.

22.  Miyamoto S, Retana L, Soobiah V, Rentsendorj A, Phuphanich S, Rudnick J, Black K, Irvin DK, Temozolomide promotes immunoresistance in surviving glioma cells via Stat3 activation and subsequent B7-H1 and B7-H4 upregulation. In Submission, PlosOne

Book Chapter

Book Chapter: The Textbook of Nanoneurosurgery, 2013 Edited by: Babak Kateb & John D. Heiss, Immune Based Targeting in Cancer Dwain K. Irvin, Chirag Patil, Keith Black. ISBN-10: 1439849412.